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Patrick J Klein Selected Research

2- (2- chloro- 4- iodophenylamino)- N- cyclopropylmethoxy- 3,4- difluoro- 5- bromobenzamide

6/2009Resistance to mitogen-activated protein kinase kinase (MEK) inhibitors correlates with up-regulation of the MEK/extracellular signal-regulated kinase pathway in hepatocellular carcinoma cells.
1/2006The effects of a novel MEK inhibitor PD184161 on MEK-ERK signaling and growth in human liver cancer.

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Patrick J Klein Research Topics

Disease

15Neoplasms (Cancer)
01/2019 - 01/2006
4Hepatocellular Carcinoma (Hepatoma)
06/2009 - 01/2006
3Inflammation (Inflammations)
10/2021 - 04/2011
2Neutropenia
12/2018 - 01/2013
2Carcinoma (Carcinomatosis)
12/2018 - 01/2013
2Rheumatoid Arthritis
07/2015 - 04/2011
2Experimental Arthritis
07/2015 - 04/2011
2Constipation
02/2011 - 12/2009
2Neuroblastoma
07/2006 - 01/2006
1Cytokine Release Syndrome
10/2021
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
01/2019
1Osteosarcoma (Osteogenic Sarcoma)
01/2019
1Carcinogenesis
01/2015
1Urinary Bladder Neoplasms (Bladder Cancer)
01/2013
1Neoplasm Metastasis (Metastasis)
01/2013
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
11/2012
1Ovarian Epithelial Carcinoma
11/2012
1Ovarian Neoplasms (Ovarian Cancer)
11/2012
1Arthritis (Polyarthritis)
04/2011
1Anaphylaxis (Anaphylactic Shock)
09/2009
1Hypersensitivity (Allergy)
09/2009
1Hepatitis
06/2009
1Liver Neoplasms (Liver Cancer)
01/2006
1Hyperplasia
07/2002
1Aflatoxin Poisoning
07/2002
1Weight Gain
07/2002
1Long Term Adverse Effects
07/2002

Drug/Important Bio-Agent (IBA)

12Folic Acid (Vitamin M)FDA LinkGeneric
01/2019 - 09/2009
6Pharmaceutical PreparationsIBA
12/2018 - 09/2009
4EC145IBA
11/2012 - 09/2009
4Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
06/2009 - 01/2006
3tubulysin BIBA
06/2017 - 09/2009
3HydrazinesIBA
04/2016 - 12/2009
3AlkaloidsIBA
11/2012 - 12/2009
2Chimeric Antigen ReceptorsIBA
10/2021 - 01/2019
2Fluorescein (Funduscein)FDA LinkGeneric
01/2019 - 09/2009
2Fluorescein-5-isothiocyanate (FITC)IBA
01/2019 - 09/2009
2LigandsIBA
01/2019 - 11/2012
2EC0531IBA
12/2018 - 06/2017
2EC0305IBA
06/2017 - 09/2009
2U 0126 (UO 126)IBA
06/2009 - 01/2006
2Mitogen-Activated Protein KinasesIBA
06/2009 - 07/2006
22- (2- chloro- 4- iodophenylamino)- N- cyclopropylmethoxy- 3,4- difluoro- 5- bromobenzamideIBA
06/2009 - 01/2006
1InterleukinsIBA
10/2021
1Folate Receptor 2IBA
10/2021
1Interleukin-6 (Interleukin 6)IBA
10/2021
1isothiocyanic acidIBA
01/2019
1Mannitol (Osmitrol)FDA LinkGeneric
04/2016
1AcetoneIBA
04/2016
1Antineoplastic Agents (Antineoplastics)IBA
04/2016
1Acetic Acid (Vinegar)FDA LinkGeneric
04/2016
1BuffersIBA
04/2016
1Alanine (L-Alanine)FDA Link
04/2016
1HydrazonesIBA
04/2016
1EC0565IBA
07/2015
1CarcinogensIBA
01/2015
1EC0905IBA
01/2013
1Cytochrome P-450 CYP2E1 (CYP2E1)IBA
12/2011
1Etanercept (Enbrel)FDA Link
04/2011
1EC 0746IBA
04/2011
1Methotrexate (Mexate)FDA LinkGeneric
04/2011
1AminopterinIBA
04/2011
1EC 0489IBA
02/2011
1HaptensIBA
09/2009
1Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
06/2009
1Proteins (Proteins, Gene)FDA Link
06/2009
1Mitogen-Activated Protein Kinase 3IBA
06/2009
11,3-butadiene (divinyl)IBA
06/2009
1mirdametinibIBA
01/2008
1Transforming Growth Factor alpha (TGF-alpha)IBA
01/2008
1Phosphotransferases (Kinase)IBA
07/2006
1Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
06/2006
1Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA
06/2006
1parthenolideIBA
06/2006
1N- (2- cyclohexyloxy- 4- nitrophenyl)methanesulfonamideIBA
06/2006
1NF-kappa B (NF-kB)IBA
06/2006
1Butylated Hydroxytoluene (BHT)IBA
07/2002
1AntioxidantsIBA
07/2002

Therapy/Procedure

6Therapeutics
10/2021 - 07/2006
2Drug Therapy (Chemotherapy)
01/2019 - 06/2006
1Intravenous Injections
11/2012
1Immunotherapy
09/2009
1Chemoprevention
01/2008